• Principle Investigator

    Tyler McQuade

    mcquade@chem.fsu.edu

    Dr. Tyler McQuade recently joined the Organic Division of the FSU Department of Chemistry and Biochemistry as Associate Professor. An Assistant Professor at Cornell University from 2001-2007, Professor McQuade graduated from the University of California - Irvine with a B.S. in Chemistry and a B.S. in Biology in 1992, and from the University of Wisconsin – Madison with a PhD in Chemistry in 1998.  He received a number of awards, including the prestigious ACS graduate fellowship, as a graduate student working under the guidance of Professor Samuel Gellman.  In addition, one of the surfactants for solubilizing membrane proteins described in his Ph.D. thesis has recently become commercially available. His post-doctorate research with Professor Timothy Swager at MIT was supported by an NIH Fellowship.

    Dr. McQuade’s current research combines the organic, bioorganic and materials chemistry of his undergraduate, graduate and post-doc work to focus on creating multi-catalyst systems that will improve the quality and efficiency of chemical synthesis. His group’s long-term goal is to advance medical and biological research by creating multi-catalyst systems that provide access to new intermediates, yield more selective reactions, and allow the construction of many bonds in one vessel.

    With a deep interest in sustainable chemistry (a more environmentally benign approach to science), Dr. McQuade and his group are working to make chemical synthesis - especially pharmaceutical production - less wasteful and expensive than it is now.  His group’s multidisciplinary environment is yielding both polymers and small molecules that will provide the building blocks for next generation methodology and new tools for sustainable process chemistry.  McQuade was a Dreyfus, 3M, Rohm and Haas, Beckman, and NYSTAR Young Investigator and was one of MIT Tech Review’s Top 100 Young Innovators in 2004. 

     

  • Research

    Our research

    The McQuade Group’s overarching goal is a more complete understanding of chemical systems.  We approach this goal by 1) creating new chemical systems that combine multiple catalysts to synthesize a desired compound in a single chemical operation and 2) creating small molecules designed to control natural biosynthetic systems (otherwise known as nature’s own multicatalyst systems). 

    These two approaches converge in our latest research focus: using multi-catalytic systems to design drugs that inhibit natural multicatalyst systems. One example of this synergy is our recent discovery of an antibiotic combination that provides excellent activity towards the bacteria which cause neonatal meningitis.  Students who participate in McQuade Group research will not only learn to synthesize compounds but will also apply those compounds to important applications with the potential to benefit both public health and the chemical industry.  Synthesis in the McQuade Group is dominated by the development of new catalytic reactions.  In some cases, we combine two or more catalysts in a single reaction vessel to perform complex tandem reactions. 

    We also perform complex synthesis by using microfluidic devices.  These outstanding tools - imported from chemical engineering - allow ultrafast mixing, rapid heat transfer, and enable multistep synthesis without purification.  Experiment by experiment, we challenge ourselves to make every route we generate as green as possible.  The push towards green chemistry drives many of today’s chemical innovations, and the McQuade Group is proud to be an active partner in that movement. 

     

  • Group

    Current Students


    Ashley Longstreet

    First Year Graduate Student

    Houjeiry, Tania

    Third Year Gradaute Student

    Zane Miller

    First Year Graduate Student

    Opalka, Suzie

    Fourth Year Graduate Student

    Park, Jin Kyoon

    Post-Doctoral Scholar

    Ondrusek, Brian

    First Year Graduate Student

    Alumni


  • Publications
    J. Am. Chem. Soc. 2011, 133 (8), pp 2410–2413

    Stereoconvergent Synthesis of Chiral Allylboronates from an E/Z Mixture of Allylic Aryl Ethers Using a 6-NHC−Cu(I) Catalyst

    J. Am. Chem. Soc. 2011, 133 (8), pp 2410–2413
    Jin Kyoon Park, Hershel H. Lackey, Brian A. Ondrusek, and D. Tyler McQuade

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    Org. Lett. 2010, 12, 5008-5011

    A Chiral 6-Membered N-Heterocyclic Carbene Copper(I) Complex That Induces High Stereoselectivity

    Org. Lett. 2010, 12, 5008-5011
    Park, Jin Kyoon, Lackey, Hershel H., Rexford, Matthew D., Kovnir, Kirill, Shatruk, Michael, McQuade, D. Tyler

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    Angew. Chem. Int. Ed. 2009, 48, 8547-8550

    The Continuous-Flow Synthesis of Ibuprofen

    Angew. Chem. Int. Ed. 2009, 48, 8547-8550
    Bogdan, Andrew R., Poe, Sarah L., Kubis, Daniel C., Broadwater, Steven J., McQuade, D. Tyler

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    Beilstein J. Org. Chem. 2009, 5,Number: 17

    A biphasic oxidation of alcohols to aldehydes and ketones using a simplified packed-bed microreactor

    Beilstein J. Org. Chem. 2009, 5,Number: 17
    Bogdan, Andrew and McQuade, D. Tyler

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    Org. Lett. 2009, 11, 479-1482

    Microcapsules with Three Orthogonal Reactive Sites

    Org. Lett. 2009, 11, 479-1482
    Mason, Brian P., Hira, Steven M., Strouse, Geoffrey F., McQuade, D. Tyler

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    J. Org. Chem. 2009, 74, 1574-1580

    Use of Bifunctional Ureas to Increase the Rate of Proline-Catalyzed alpha-Aminoxylations

    J. Org. Chem. 2009, 74, 1574-1580
    Poe, Sarah L., Bogdan, Andrew R., Mason, Brian P., Steinbacher, Jeremy L., Opalka, Suzanne M., McQuade, D. Tyler

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    Journal of Polymer Science A 2008, 46, 2309-2315

    Creating microenvironments using encapsulated polymers

    Journal of Polymer Science A 2008, 46, 2309-2315
    Kobaslija, Muris, Bogdan, Andrew R., Poe, Sarah L., Escobedo, Fernando, McQuade, D. Tyler

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    Org. Lett. 2006, 9, 3449-3451

    A general approach to creating soluble catalytic polymers heterogenized in microcapsules

    Org. Lett. 2006, 9, 3449-3451
    Mason, Brian P., Bogdan, Andrew R., Goswami, Anandarup, McQuade, D. Tyler

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    J. Am. Chem. Soc. 2007, 129, 9216-9221

    Mechanism and application of a microcapsule enabled multicatalyst reaction

    J. Am. Chem. Soc. 2007, 129, 9216-9221
    Poe, Sarah L., Kobaslija, Muris, McQuade, D. Tyler

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    Chem Rev. 2007, 107, 2300-2318

    Greener approaches to organic synthesis using microreactor technology

    Chem Rev. 2007, 107, 2300-2318
    Mason, Brian P., Price, Kristin E., Steinbacher, Jeremy L., Bogdan, Andrew R., McQuade, D. Tyler

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    Angew. Chem.-Int. Ed. 2007, 46, 1698-170

    Improving solid-supported catalyst productivity by using simplified packed-bed microreactors

    Angew. Chem.-Int. Ed. 2007, 46, 1698-170
    Bogdan, Andrew R., Mason, Brian P.,Sylvester, Kevin T. and McQuade, D. Tyler

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    J. Am. Chem. Society 2006, 128, 15586-15587

    Microcapsule enabled multicatalyst system

    J. Am. Chem. Society 2006, 128, 15586-15587
    Poe, Sarah L., Kobaslija, Muris and McQuade, D. Tyler

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    Journal of Polymer Science A, 2006, 44, 6505-6533

    Polymer chemistry in flow: New polymers, beads, capsules, and fibers

    Journal of Polymer Science A, 2006, 44, 6505-6533
    Jeremy Steinbacher and D. Tyler McQuade

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    Macromolecules 2006, 39,7681-7685

    Self-diffusion of linear polymers within microcapsules

    Macromolecules 2006, 39,7681-7685
    Price KE, Broadwater SJ, Bogdan AR, Keresztes I, Steinbacher JL , McQuade DT

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    Macromolecules 2006, 39, 6371-6375

    Polyurea microcapsules from oil-in-oil emulsions via interfacial polymerization

    Macromolecules 2006, 39, 6371-6375
    Muris Kobaslija and D. Tyler McQuade

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    Biomacromolecules 2006, 7, 2357-2361

    Removable colored coatings based on calcium alginate hydrogels

    Biomacromolecules 2006, 7, 2357-2361
    Muris Kobaslija and D. Tyler McQuade

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    J. Amer. Chem. Soc. 2006, 128 (32),10376-10377

    Microencapsulated linear polymers: "Soluble" heterogeneous catalysts

    J. Amer. Chem. Soc. 2006, 128 (32),10376-10377
    Price KE (Price, Kristin E.), Mason BP (Mason, Brian P.), Bogdan AR (Bogdan, Andrew R.), Broadwater SJ (Broadwater, Steven J.), Steinbacher JL (Steinbacher, Jeremy L.), McQuade DT (McQuade, D. Tyler)

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    J. Amer. Chem. Soc. 2006, 128 (29), 9442-9447

    Rapid self-assembly of core-shell organosilicon microcapsules within a microfluidic device

    J. Amer. Chem. Soc. 2006, 128 (29), 9442-9447
    Steinbacher JL (Steinbacher, Jeremy L.), Moy RWY (Moy, Rebecca W. Y.), Price KE (Price, Kristin E.), Cummings MA (Cummings, Meredith A.), Roychowdhury C (Roychowdhury, Chandrani), Buffy JJ (Buffy, Jarrod J.), Olbricht WL (Olbricht, William L.), Haaf M (Haaf, Michael), McQuade DT (McQuade, D. Tyler)

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    J. Polymer Sc. part A-Polymer Chemistry. 2006, 44 (10), 3271-3278

    Substituted sergeants influencing the deoxy soldiers in folded oligonucleotides

    J. Polymer Sc. part A-Polymer Chemistry. 2006, 44 (10), 3271-3278
    Park JI, Roth SL, Price KE, Mcquade DT

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    J. Org. Chem. 2006, 71(5), 2131-2134

    Investigating PdEnCat catalysis

    J. Org. Chem. 2006, 71(5), 2131-2134
    Broadwater SJ, McQuade DT

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    Angew. Chem. Int. Ed. 2006, 45 (10), 1544- 1548

    Solving the clogging problem: Precipitate-forming reactions in flow

    Angew. Chem. Int. Ed. 2006, 45 (10), 1544- 1548
    Poe SL, Cummings MA, Haaf MR, McQuade DT

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    Org. Bio. Chem. 2005, 3, 2899-2906

    One-pot multi-step synthesis: a challenge spawning innovation

    Org. Bio. Chem. 2005, 3, 2899-2906
    Broadwater SJ, Roth SL, Price KE, Kobaslija M, McQuade DT

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    J. Am. Chem. Soc. 2005, 127, 10498-10499

    Interfacial polymerization within a simplified microfluidic device: Capturing capsules

    J. Am. Chem. Soc. 2005, 127, 10498-10499
    Elizabeth Quevedo, Jeremy Steinbacher, and D. Tyler McQuade

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    J. Org. Chem. 2005, 70, 3980-3987

    A new interpretation of the Baylis-Hillman mechanism

    J. Org. Chem. 2005, 70, 3980-3987
    Price KE, Broadwater SJ, Walker BJ, McQuade DT

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    Chem Comm 2005, 1714-1716

    A cross-linked reverse micelle-encapsulated palladium catalyst

    Chem Comm 2005, 1714-1716
    Price KE, McQuade DT

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    Org. Lett. 2005, 7, 147-150

    Baylis-Hillman mechanism: A new interpretation in aprotic solvents

    Org. Lett. 2005, 7, 147-150
    Price KE, Broadwater SJ, Jung HM, McQuade DT

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    J. Am. Chem. Soc. 2003, 125, 11154-11155

    A comparison of crystalline- and graft polymer-based chemosensors

    J. Am. Chem. Soc. 2003, 125, 11154-11155
    Broadwater SJ, Hickey MK, McQuade DT

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    J. Am. Chem. Soc. 2003, 125, 5351-5355

    Synthesis and characterization of cross-linked reverse micelles

    J. Am. Chem. Soc. 2003, 125, 5351-5355
    Jung HM, Price KE, McQuade DT

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Copyright • Florida State University • Department of Chemistry • The McQuade Group • 2008—2009
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